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It has been proven that Poppers are largely harmless when used correctly, responsibly and in moderation. Following a few simple rules reduces the risks massively. Nevertheless, despite the manageable duration of action, there are some risks to which we would like to draw your attention unequivocally on this page:
The inhalation of Poppers has a very strong vasodilatory effect. There is a sudden dilation of the blood vessels and a brief drop in blood pressure for one minute with an increased pulse rate. Consumption together with Viagra or Kamagra is life-threatening as it can lead to an excessive drop in blood pressure. We expressly advise against combining it with any products containing the active ingredient sildenafil.2 Danger to life!
The inhalation of Poppers leads to a temporary lack of oxygen in the brain. Excessive consumption can lead to severe headaches or even temporary unconsciousness and stroke symptoms.3 In this case, you should immediately open the window and provide fresh air and call an emergency doctor (116117).
Direct contact with skin, mucous membranes and eyes should be avoided at all costs, as Poppers have a corrosive effect. In case of contact with skin, mucous membranes and eyes, rinse immediately with water.
Take care when transporting bottles of Poppers in your trouser pocket or when carrying them directly on your body. Accidental leakage of the liquid can lead to burns.5 Therefore, use the Poppers Keeper for safe transportation.
Never drink Poppers! Ingestion can be fatal. They contain chemically aggressive substances that are highly corrosive and toxic. If someone accidentally drinks Poppers, never make the person vomit, but drink plenty of water. Call 112 immediately and keep the bottle for the emergency services.
Unfortunately, a small number of deaths occur every year due to the accidental drinking of Poppers. In the UK, there were 5 deaths from drinking Poppers between 1987 and 2018.6 Don’t keep Poppers in the fridge where they can be mistaken for energy drinks or ginger shots by family members, flatmates, friends or visitors.
Poppers containing isobutyl nitrite or isopropyl nitrite are very toxic if inhaled and potentially carcinogenic. Isopropyl nitrite can also cause eye damage.7 We distance ourselves from these Poppers and do not sell them on this site. Therefore, always make sure that the nitrite is clearly declared on the bottle. The ingredients in Poppers pose different health risks. You can select Poppers that are classified as less harmful to your health by being informed.
If you are taking antihypertensive medication, cardiovascular medication or medication for respiratory diseases, special care is required. Mixing Poppers with medication or drugs is dangerous. Please contact your doctor in advance and clarify the interaction with Poppers. People who suffer from cardiovascular and brain diseases should refrain from using Poppers. 8
Excessive consumption of Poppers can lead to retinal damage.9 Therefore, pay attention to eye health when using poppers.
The nitrites in the Poppers are highly flammable.10 Therefore, take care when smoking, using candles and lighters. Also make sure that no liquid gets on your hands, which can also catch fire when lighting a cigarette. Only use Poppers in well-ventilated rooms.
Do you have any further questions about the risks and side effects of Poppers? Ask us or contact advice centers such as sidekicks.berlin.
1 Nutt, David et al. Development of a rational scale to assess the harm of drugs of potential misuse. The Lancet, Volume 369, Issue 9566, 1047 – 1053.
2 Kloner, R.A. (2010). Drug Interactions With Phosphodiesterase-5 Inhibitors Used for the Treatment of Erectile Dysfunction or Pulmonary Hypertension. Circulation, 122(1), 88-95.
3 Aronson, J.K. (2016) ‘Nitrates, organic’, in Meyler’s Side Effects of Drugs. 16th edn. Amsterdam: Elsevier, pp. 192-202.
4 Vaccher SJ, Hammoud MA, Bourne A, Lea T, Haire BG, Holt M, Saxton P, Mackie B, Badge J, Jin F, Maher L, Prestage G. Prevalence, frequency, and motivations for alkyl nitrite use among gay, bisexual and other men who have sex with men in Australia. Int J Drug Policy. 2020 Feb;76:102659. doi: 10.1016/j.drugpo.2019.102659. Epub 2020 Jan 8. PMID: 31927224.
5 Moret F, Lindner G, Woitok BK. The Untimely Popping Phial: Poppers as an Unusual Cause of Skin Corrosion of the Thigh. Case Rep Emerg Med. 2020 Jan 30;2020:2058624. doi: 10.1155/2020/2058624. PMID: 32082645; PMCID: PMC7011308.
6 Corkery, J.M.; Copeland, C.S.; Ream, S.; Streete, P.; Schifano, F. An Update on Deaths in the United Kingdom from ‘Poppers’ (Alkyl Nitrites), with a Particular Focus on ‘Swallowing’ Fatalities. J. Clin. Med. 2025, 14, 427. https://doi.org/10.3390/jcm14020427
7 Rewbury R, Hughes E, Purbrick R, et al
Poppers: legal highs with questionable contents? A case series of Poppers maculopathy
British Journal of Ophthalmology 2017;101:1530-1534.
8 Advisory Council on the Misuse of Drugs (ACMD). (2024). Updated harms assessment of alkyl nitrites (“poppers”) and consideration of exemption from the Psychoactive Substances Act 2016 (Home Office publication). UK Government. https://www.gov.uk/government/publications
9 Davies, A., Kelly, S., Naylor, S. et al. Adverse ophthalmic reaction in Poppers users: case series of ‘poppers maculopathy’. Eye 26, 1479-1486 (2012). https://doi.org/10.1038/eye.2012.191
10 Haverkos, H.W.; Dougherty, J.A. Health Hazards of Nitrite Inhalants, NIDA Research Monograph 83 (Rockville, MD: National Institute on Drug Abuse, 1988), https://archives.nida.nih.gov/sites/default/files/monograph83.pdf.
